Phosphorylated TDP-43 aggregates in skeletal and cardiac muscle are a marker of myogenic degeneration in amyotrophic lateral sclerosis and various conditions

BACKGROUND: Amyotrophic lateral sclerosis (ALS) is characterized pathologically by the occurrence of phosphorylated TDP-43 (pTDP-43)-immunoreactive neuronal and glial inclusions in the central nervous system. Recent studies have shown that pTDP-43 aggregates also occur in the skeletal muscles in a c...

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Vydáno v:Acta Neuropathol Commun
Hlavní autoři: Mori, Fumiaki, Tada, Mari, Kon, Tomoya, Miki, Yasuo, Tanji, Kunikazu, Kurotaki, Hidekachi, Tomiyama, Masahiko, Ishihara, Tomohiko, Onodera, Osamu, Kakita, Akiyoshi, Wakabayashi, Koichi
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2019
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6816170/
https://ncbi.nlm.nih.gov/pubmed/31661037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-019-0824-1
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