Divergent roles of astrocytic versus neuronal EAAT2 deficiency on cognition and overlap with aging and Alzheimer’s molecular signatures

The excitatory amino acid transporter 2 (EAAT2) is the major glutamate transporter in the brain expressed predominantly in astrocytes and at low levels in neurons and axonal terminals. EAAT2 expression is reduced in aging and sporadic Alzheimer’s disease (AD) patients’ brains. The role EAAT2 plays i...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Sharma, Abhijeet, Kazim, Syed Faraz, Larson, Chloe S., Ramakrishnan, Aarthi, Gray, Jason D., McEwen, Bruce S., Rosenberg, Paul A., Shen, Li, Pereira, Ana C.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6815169/
https://ncbi.nlm.nih.gov/pubmed/31591195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1903566116
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