TNF receptor 2 signaling prevents DNA methylation at the Foxp3 promoter and prevents pathogenic conversion of regulatory T cells

Regulatory T (Treg) cells expressing the transcription factor Foxp3 play an important role in maintaining immune homeostasis. Chronic inflammation is associated with reduced Foxp3 expression, function, and loss of phenotypic stability. Previous studies have established the importance of TNF receptor...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Tseng, Wen-Yi, Huang, Yi-Shu, Clanchy, Felix, McNamee, Kay, Perocheau, Dany, Ogbechi, Joy, Luo, Shue-Fen, Feldmann, Marc, McCann, Fiona E., Williams, Richard O.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2019
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6815167/
https://ncbi.nlm.nih.gov/pubmed/31597740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1909687116
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