Fast-diffusing p75(NTR) monomers support apoptosis and growth cone collapse by neurotrophin ligands

The p75 neurotrophin (NT) receptor (p75(NTR)) plays a crucial role in balancing survival-versus-death decisions in the nervous system. Yet, despite 2 decades of structural and biochemical studies, a comprehensive, accepted model for p75(NTR) activation by NT ligands is still missing. Here, we presen...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Marchetti, Laura, Bonsignore, Fulvio, Gobbo, Francesco, Amodeo, Rosy, Calvello, Mariantonietta, Jacob, Ajesh, Signore, Giovanni, Schirripa Spagnolo, Chiara, Porciani, David, Mainardi, Marco, Beltram, Fabio, Luin, Stefano, Cattaneo, Antonino
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
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PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6815156/
https://ncbi.nlm.nih.gov/pubmed/31515449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1902790116
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