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Fitness effects but no temperature-mediated balancing selection at the polymorphic Adh gene of Drosophila melanogaster

Polymorphism in the alcohol dehydrogenase (ADH) protein of Drosophila melanogaster, like genetic variation in many other enzymes, has long been hypothesized to be maintained by a selective trade-off between thermostability and enzyme activity. Two major Adh variants, named Fast and Slow, are distrib...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Siddiq, Mohammad A., Thornton, Joseph W.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6815130/
https://ncbi.nlm.nih.gov/pubmed/31594844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1909216116
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