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ATXN1 N-terminal region explains the binding differences of wild-type and expanded forms
BACKGROUND: Wild-type (wt) polyglutamine (polyQ) regions are implicated in stabilization of protein-protein interactions (PPI). Pathological polyQ expansion, such as that in human Ataxin-1 (ATXN1), that causes spinocerebellar ataxia type 1 (SCA1), results in abnormal PPI. For ATXN1 a larger number o...
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| Publicado no: | BMC Med Genomics |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6814966/ https://ncbi.nlm.nih.gov/pubmed/31655597 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12920-019-0594-4 |
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