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Cre/lox generation of a novel whole-body Kiss1r KO mouse line recapitulates a hypogonadal, obese, and metabolically-impaired phenotype

Kisspeptin and its receptor, Kiss1r, act in centrally to stimulate reproduction. Recent evidence indicates that kisspeptin is also important for body weight and metabolism, as whole-body Kiss1r KO mice, developed with gene trap technology, display obesity and reduced metabolism. Kiss1r is expressed...

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Dettagli Bibliografici
Pubblicato in:Mol Cell Endocrinol
Autori principali: Tolson, Kristen P., Marooki, Nuha, Wolfe, Andrew, Smith, Jeremy T., Kauffman, Alexander S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6814569/
https://ncbi.nlm.nih.gov/pubmed/31442544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mce.2019.110559
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