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Young and aged TLR4 deficient mice show sex-dependent enhancements in spatial memory and alterations in interleukin-1 related genes

Toll-like receptor-4 (TLR4) is a transmembrane receptor that initiates an immune response following a bacterial infection or host derived molecules associated with cellular distress. Beyond triggering inflammation, TLR4 has been implicated in modulating behavior and cognitive processes in a physiolo...

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Bibliographic Details
Published in:Brain Behav Immun
Main Authors: Potter, Opal V., Giedraitis, Megan E., Johnson, Charles D., Cox, Mackenzie N., Kohman, Rachel A.
Format: Artigo
Language:Inglês
Published: 2018
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6814391/
https://ncbi.nlm.nih.gov/pubmed/30394314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbi.2018.10.010
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