Gastrin vaccine improves response to immune checkpoint antibody in murine pancreatic cancer by altering the tumor microenvironment

Pancreatic cancer has been termed a ‘recalcitrant cancer’ due to its relative resistance to chemotherapy and immunotherapy. This resistance is thought to be due in part to the dense fibrotic tumor microenvironment and lack of tumor infiltrating CD8 + T cells. The gastrointestinal peptide, gastrin, h...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cancer Immunol Immunother
Prif Awduron: Osborne, Nicholas, Sundseth, Rebecca, Burks, Julian, Cao, Hong, Liu, Xunxian, Kroemer, Alexander H., Sutton, Lynda, Cato, Allen, Smith, Jill P.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Springer Berlin Heidelberg 2019
Pynciau:
Original Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6814262/
https://ncbi.nlm.nih.gov/pubmed/31549214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-019-02398-6
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