Prenatal Treatment of X-Linked Hypohidrotic Ectodermal Dysplasia Using Recombinant Ectodysplasin in a Canine Model

X-linked hypohidrotic ectodermal dysplasia (XLHED) is caused by defects in the EDA gene that inactivate the function of ectodysplasin A1 (EDA1). This leads to abnormal development of eccrine glands, hair follicles, and teeth, and to frequent respiratory infections. Previous studies in the naturally...

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Vydáno v:J Pharmacol Exp Ther
Hlavní autoři: Margolis, Carol A., Schneider, Pascal, Huttner, Kenneth, Kirby, Neil, Houser, Timothy P., Wildman, Lee, Grove, Gary L., Schneider, Holm, Casal, Margret L.
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Pharmacology and Experimental Therapeutics 2019
Témata:
Special Issue on Drug Delivery Technologies
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6812859/
https://ncbi.nlm.nih.gov/pubmed/31000577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.118.256040
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