Ebola virus-mediated T-lymphocyte depletion is the result of an abortive infection

Ebola virus (EBOV) infections are characterized by a pronounced lymphopenia that is highly correlative with fatalities. However, the mechanisms leading to T-cell depletion remain largely unknown. Here, we demonstrate that both viral mRNAs and antigens are detectable in CD4(+) T cells despite the abs...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Younan, Patrick, Santos, Rodrigo I., Ramanathan, Palaniappan, Iampietro, Mathieu, Nishida, Andrew, Dutta, Mukta, Ammosova, Tatiana, Meyer, Michelle, Katze, Michael G., Popov, Vsevolod L., Nekhai, Sergei, Bukreyev, Alexander
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6812753/
https://ncbi.nlm.nih.gov/pubmed/31648236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008068
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