Mannose Phosphate Isomerase and Mannose Regulate Hepatic Stellate Cell Activation and Fibrosis in Zebrafish and Humans

The growing burden of liver fibrosis and lack of effective antifibrotic therapies highlight the need for identification of pathways and complementary model systems of hepatic fibrosis. A rare, monogenic disorder in which children with mutations in mannose phosphate isomerase (MPI) develop liver fibr...

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Veröffentlicht in:Hepatology
Hauptverfasser: DeRossi, Charles, Bambino, Kathryn, Morrison, Joshua, Sakarin, Isabel, Villacorta-Martin, Carlos, Zhang, Changwen, Ellis, Jillian L., Fiel, M. Isabel, Ybanez, Maria, Lee, Youngmin A., Huang, Kuan-lin, Yin, Chunyue, Sakaguchi, Takuya F., Friedman, Scott L., Villanueva, Augusto, Chu, Jaime
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6812593/
https://ncbi.nlm.nih.gov/pubmed/31016744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.30677
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