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Mannose Phosphate Isomerase and Mannose Regulate Hepatic Stellate Cell Activation and Fibrosis in Zebrafish and Humans

The growing burden of liver fibrosis and lack of effective antifibrotic therapies highlight the need for identification of pathways and complementary model systems of hepatic fibrosis. A rare, monogenic disorder in which children with mutations in mannose phosphate isomerase (MPI) develop liver fibr...

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Detalhes bibliográficos
Publicado no:Hepatology
Main Authors: DeRossi, Charles, Bambino, Kathryn, Morrison, Joshua, Sakarin, Isabel, Villacorta-Martin, Carlos, Zhang, Changwen, Ellis, Jillian L., Fiel, M. Isabel, Ybanez, Maria, Lee, Youngmin A., Huang, Kuan-lin, Yin, Chunyue, Sakaguchi, Takuya F., Friedman, Scott L., Villanueva, Augusto, Chu, Jaime
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6812593/
https://ncbi.nlm.nih.gov/pubmed/31016744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.30677
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