Impaired adult hippocampal neurogenesis in a mouse model of familial hypercholesterolemia: A role for the LDL receptor and cholesterol metabolism in adult neural precursor cells

OBJECTIVE: In familial hypercholesterolemia (FH), mutations in the low-density lipoprotein (LDL) receptor (LDLr) gene result in increased plasma LDL cholesterol. Clinical and preclinical studies have revealed an association between FH and hippocampus-related memory and mood impairment. We here asked...

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Publicado en:Mol Metab
Autores principales: Engel, Daiane F., Grzyb, Anna N., de Oliveira, Jade, Pötzsch, Alexandra, Walker, Tara L., Brocardo, Patricia S., Kempermann, Gerd, de Bem, Andreza F.
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2019
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6812372/
https://ncbi.nlm.nih.gov/pubmed/31767163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2019.09.002
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