AMPK-mediated senolytic and senostatic activity of quercetin surface functionalized Fe(3)O(4) nanoparticles during oxidant-induced senescence in human fibroblasts

Cellular senescence may contribute to aging and age-related diseases and senolytic drugs that selectively kill senescent cells may delay aging and promote healthspan. More recently, several categories of senolytics have been established, namely HSP90 inhibitors, Bcl-2 family inhibitors and natural c...

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Vydáno v:Redox Biol
Hlavní autoři: Lewinska, Anna, Adamczyk-Grochala, Jagoda, Bloniarz, Dominika, Olszowka, Jakub, Kulpa-Greszta, Magdalena, Litwinienko, Grzegorz, Tomaszewska, Anna, Wnuk, Maciej, Pazik, Robert
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2019
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6812309/
https://ncbi.nlm.nih.gov/pubmed/31622846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2019.101337
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