Resistin expression in human monocytes is controlled by two linked promoter SNPs mediating NFKB p50/p50 binding and C-methylation

Resistin is a key cytokine associated with metabolic and inflammatory diseases. Especially in East Asian populations, the expression levels are strongly influenced by genetic polymorphisms. Mechanisms and functional implications of this genetic control are still unknown. By employing reporter assays...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Kumar, Dilip, Lee, Bernett, Puan, Kia Joo, Lee, Wendy, Luis, Boris San, Yusof, Nurhashikin, Andiappan, Anand Kumar, Del Rosario, Ricardo, Poschmann, Jeremie, Kumar, Pavanish, DeLibero, Gennaro, Singhal, Amit, Prabhakar, Shyam, De Yun, Wang, Poidinger, Michael, Rötzschke, Olaf
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2019
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6811637/
https://ncbi.nlm.nih.gov/pubmed/31645609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-51592-0
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