Cardiac Pacemaker Cells Generate Cardiomyocytes from Fibroblasts in Long-Term Cultures

Because cardiomyocyte generation is limited, the turnover of cardiomyocytes in adult heart tissues is much debated. We report here that cardiac pacemaker cells can generate cardiomyocytes from fibroblasts in vitro. Sinoatrial node cells (SANCs) were isolated from adult guinea pig hearts and were cul...

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Pubblicato in:Sci Rep
Autori principali: Kiuchi, Shigeki, Usami, Akino, Shimoyama, Tae, Otsuka, Fuminori, Yamaguchi, Sachiko, Nakamura, Tomonori, Suzuki, Shigeto, Ono, Kageyoshi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6811548/
https://ncbi.nlm.nih.gov/pubmed/31645588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-51001-6
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