722. Pharmacokinetics (PK) and Safety of Lefamulin (LEF) After Single Intravenous Dose Administration in Subjects With Impaired Hepatic Function

BACKGROUND: Patients with chronic liver disease (CLD) have impaired immune function, are prone to community-acquired bacterial pneumonia (CABP), and experience greater morbidity/mortality and healthcare costs than CABP patients without CLD. LEF, a novel pleuromutilin antibiotic (IV/oral) with primar...

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Pubblicato in:Open Forum Infect Dis
Autori principali: Wicha, Wolfgang, Marbury, Thomas C, Dowell, James A, Lykens, Lori, Leister, Cathie, Ermer, James, Gelone, Steven P
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2019
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Abstracts
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6810932/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ofid/ofz360.790
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