1533. Is Cation-Adjusted Mueller–Hinton Broth (CAMHB) Appropriate for Metallo-β-lactamase (MBL) Susceptibility Testing? Novel Insights in In Vitro–In Vivo Discordance Among MBL-Producing Enterobacteriaceae

BACKGROUND: MBLs, which require Zn for catalytic activity, are a major contributor to high-level β-lactam resistance when tested using conventional CAMHB. We have previously reported marked reductions in meropenem (MEM) MICs in Zn-depleted media (Chelex-CAMHB and EDTA-CAMHB; Zn [C] <0.002 mg/L) c...

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I publikationen:Open Forum Infect Dis
Huvudupphovsmän: Asempa, Tomefa E, Abdelraouf, Kamilia, Nicolau, David P
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2019
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Abstracts
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6810773/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ofid/ofz360.1397
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