Synthesis and in vivo evaluation of [(18)F]UCB-J for PET imaging of synaptic vesicle glycoprotein 2A (SV2A)

PURPOSE: Synaptic abnormalities have been implicated in a variety of neuropsychiatric disorders, including epilepsy, Alzheimer’s disease, and schizophrenia. Hence, PET imaging of the synaptic vesicle glycoprotein 2A (SV2A) may be a valuable in vivo biomarker for neurologic and psychiatric diseases....

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Pubblicato in:Eur J Nucl Med Mol Imaging
Autori principali: Li, Songye, Cai, Zhengxin, Zhang, Wenjie, Holden, Daniel, Lin, Shu-fei, Finnema, Sjoerd J., Shirali, Anupama, Ropchan, Jim, Carre, Stephane, Mercier, Joel, Carson, Richard E., Nabulsi, Nabeel, Huang, Yiyun
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6810698/
https://ncbi.nlm.nih.gov/pubmed/31175396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00259-019-04357-w
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