2755. Phase 1/2, First-in-Human Study of the Safety, Tolerability, and Immunogenicity of an RSV Prefusion F-Based Subunit Vaccine Candidate

BACKGROUND: The respiratory syncytial virus (RSV) fusion glycoprotein (F) is a molecule that fuses the viral and host cell membranes during virus entry as it rearranges from a meta-stable prefusion to a stable postfusion conformation. Using structure-guided design, Pfizer engineered a prefusion RSV...

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Bibliographische Detailangaben
Veröffentlicht in:Open Forum Infect Dis
Hauptverfasser: Schmoele-Thoma, Beate, Falsey, Ann R, Walsh, Edward E, Swanson, Kena, Zareba, Agnieszka, Cooper, David, Gruber, William C, Jansen, Kathrin U, Radley, David, Scott, Daniel, Dormitzer, Philip R
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2019
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Abstracts
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6809502/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ofid/ofz360.2432
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