974. PD-1 Immune Checkpoint Blockade Improves Survival and Promotes Fungal Clearance in an Immunosuppressed Murine Invasive Pulmonary Aspergillosis (IPA) Model

BACKGROUND: Checkpoint blockade (CPB) has brought a revolution in modern oncology and may offer new strategies for antifungal immunotherapy. In vitro studies have demonstrated that blockade of the PD-1/PDL-1 interaction increased IFN-γ secretion in response to Aspergillus antigens, suggesting a pote...

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Détails bibliographiques
Publié dans:Open Forum Infect Dis
Auteurs principaux: Wurster, Sebastian, Robinson, Prema, Albert, Nathaniel D, Lionakis, Michail S, Kontoyiannis, Dimitrios P
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2019
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Abstracts
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6809042/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ofid/ofz359.076
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