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973. Single-cell RNA Sequencing Analysis of Zika Virus Infection in Human Stem Cell-Derived Cerebral Organoids

BACKGROUND: The molecular mechanisms underpinning the neurologic and congenital pathologies caused by Zika virus (ZIKV) infection remain poorly understood. One barrier has been the lack of relevant model systems for the developing human brain; however, thanks to advances in the stem cell field, we c...

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Detalhes bibliográficos
Publicado no:Open Forum Infect Dis
Main Authors: Ocwieja, Karen, Stanton, Alexandra, Richards, Alexsia, Antonucci, Jenna, Hughes, Travis, Shalek, Alex, Jaenisch, Rudolph, Gehrke, Lee
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6808757/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ofid/ofz359.075
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