Immunoglobulin somatic hypermutation has clinical impact in DLBCL and potential implications for immune checkpoint blockade and neoantigen-based immunotherapies

BACKGROUND: Diffuse large B-cell lymphoma (DLBCL) harbors somatic hypermutation (SHM) in the immunoglobulin heavy chain and light chain variable region genes, IGHV and IGK/LV. Recent studies have revealed that IGV SHM creates neoantigens that activate T-cell responses against B-cell lymphoma. METHOD...

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I publikationen:J Immunother Cancer
Huvudupphovsmän: Xu-Monette, Zijun Y., Li, Jianyong, Xia, Yi, Crossley, Beryl, Bremel, Robert D., Miao, Yi, Xiao, Min, Snyder, Thomas, Manyam, Ganiraju C., Tan, Xiaohong, Zhang, Hongwei, Visco, Carlo, Tzankov, Alexandar, Dybkaer, Karen, Bhagat, Govind, Tam, Wayne, You, Hua, Hsi, Eric D., van Krieken, J. Han, Huh, Jooryung, Ponzoni, Maurilio, Ferreri, Andrés J. M., Møller, Michael B., Piris, Miguel A., Winter, Jane N., Medeiros, Jeffrey T., Xu, Bing, Li, Yong, Kirsch, Ilan, Young, Ken H.
Materialtyp: Artigo
Språk:Inglês
Publicerad: BioMed Central 2019
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6806565/
https://ncbi.nlm.nih.gov/pubmed/31640780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40425-019-0730-x
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