LTA1 is a safe, intranasal enterotoxin-based adjuvant that improves vaccine protection against influenza in young, old and B-cell-depleted (μMT) mice

Enterotoxin-based adjuvants including cholera toxin and heat-labile toxin (LT) are powerful manipulators of mucosal immunity; however, past clinical trials identified unacceptable neurological toxicity when LT or mutant AB(5) adjuvant proteins were added to intranasal vaccines. Here, we examined the...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Valli, E., Harriett, A. J., Nowakowska, M. K., Baudier, R. L., Provosty, W. B., McSween, Z., Lawson, L. B., Nakanishi, Y., Norton, E. B.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6805908/
https://ncbi.nlm.nih.gov/pubmed/31641151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-51356-w
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