Characterization of resistance to a potent d-peptide HIV entry inhibitor

BACKGROUND: PIE12-trimer is a highly potent d-peptide HIV-1 entry inhibitor that broadly targets group M isolates. It specifically binds the three identical conserved hydrophobic pockets at the base of the gp41 N-trimer with sub-femtomolar affinity. This extremely high affinity for the transiently e...

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Publicado en:Retrovirology
Autores principales: Smith, Amanda R., Weinstock, Matthew T., Siglin, Amanda E., Whitby, Frank G., Francis, J. Nicholas, Hill, Christopher P., Eckert, Debra M., Root, Michael J., Kay, Michael S.
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6805555/
https://ncbi.nlm.nih.gov/pubmed/31640718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12977-019-0489-7
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