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Analysis of determinants for in vitro resistance to the small molecule deubiquitinase inhibitor b-AP15
BACKGROUND: b-AP15/VLX1570 are small molecule inhibitors of the ubiquitin specific peptidase 14 (USP14) and ubiquitin carboxyl-terminal hydrolase 5 (UCHL5) deubiquitinases (DUBs) of the 19S proteasome. b-AP15/VLX1570 have been shown to be cytotoxic to cells resistant to bortezomib, raising the possi...
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| Publicado en: | PLoS One |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Public Library of Science
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6804958/ https://ncbi.nlm.nih.gov/pubmed/31639138 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0223807 |
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