Combination Therapy with Reovirus and ATM Inhibitor Enhances Cell Death and Virus Replication in Canine Melanoma

Oncolytic virotherapy using reovirus is a promising new anti-cancer treatment with potential for use in humans and dogs. Because reovirus monotherapy shows limited efficacy in human and canine cancer patients, the clinical development of a combination therapy is necessary. To identify candidate comp...

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Bibliografiske detaljer
Udgivet i:Mol Ther Oncolytics
Main Authors: Igase, Masaya, Shibutani, Shusaku, Kurogouchi, Yosuke, Fujiki, Noriyuki, Hwang, Chung Chew, Coffey, Matt, Noguchi, Shunsuke, Nemoto, Yuki, Mizuno, Takuya
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Gene & Cell Therapy 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6804779/
https://ncbi.nlm.nih.gov/pubmed/31650025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omto.2019.08.003
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