A single systemic inflammatory insult causes acute motor deficits and accelerates disease progression in a mouse model of human tauopathy

INTRODUCTION: Neuroinflammation, which contributes to neurodegeneration, is a consistent hallmark of dementia. Emerging evidence suggests that systemic inflammation also contributes to disease progression. METHODS: The ability of systemically administered lipopolysaccharide (LPS - 500 μg/kg) to effe...

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Udgivet i:Alzheimers Dement (N Y)
Main Authors: Torvell, Megan, Hampton, David W., Connick, Peter, MacLullich, Alasdair M.J., Cunningham, Colm, Chandran, Siddharthan
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2019
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6804509/
https://ncbi.nlm.nih.gov/pubmed/31650014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.trci.2019.09.001
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