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Chemoenzymatic Total Synthesis of (+)-10-Keto-Oxycodone from Phenethyl Acetate †

The total synthesis of (+)-10-keto-oxycodone was attained from phenethyl acetate in a stereoselective manner. Absolute stereochemistry was established via enzymatic dihydroxylation of phenethyl acetate with the recombinant strain JM109 (pDTG601A) that furnished the corresponding cis-cyclohexadienedi...

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Pubblicato in:Molecules
Autori principali: Endoma-Arias, Mary Ann, Dela Paz, Helen, Hudlicky, Tomas
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6804203/
https://ncbi.nlm.nih.gov/pubmed/31557873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24193477
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