Systemic and Intravitreal Antagonism of the TNFR1 Signaling Pathway Delays Axotomy-Induced Retinal Ganglion Cell Loss

Here, we have blocked the signaling pathway of tumor necrosis factor α (TNFα) in a mouse model of traumatic neuropathy using a small cell permeable molecule (R7050) that inhibits TNFα/TNF receptor 1 (TNFR1) complex internalization. Adult pigmented mice were subjected to intraorbital optic nerve crus...

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Detalhes bibliográficos
Publicado no:Front Neurosci
Main Authors: Lucas-Ruiz, Fernando, Galindo-Romero, Caridad, Salinas-Navarro, Manuel, González-Riquelme, María Josefa, Vidal-Sanz, Manuel, Agudo Barriuso, Marta
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6803525/
https://ncbi.nlm.nih.gov/pubmed/31680831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2019.01096
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