Rationale for the ASSAIL-MI-trial: a randomised controlled trial designed to assess the effect of tocilizumab on myocardial salvage in patients with acute ST-elevation myocardial infarction (STEMI)

INTRODUCTION: Interleukin-6 (IL-6) may be involved in ischaemia-reperfusion injury and myocardial remodelling after myocardial infarction (MI). We have recently shown that IL-6 inhibition by tocilizumab attenuates systemic inflammation and troponin T-release in patients with acute non-ST elevation M...

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Detalhes bibliográficos
Publicado no:Open Heart
Main Authors: Anstensrud, Anne Kristine, Woxholt, Sindre, Sharma, Kapil, Broch, Kaspar, Bendz, Bjørn, Aakhus, Svend, Ueland, Thor, Amundsen, Brage H, Damås, Jan Kristian, Hopp, Einar, Kleveland, Ola, Stensæth, Knut Haakon, Opdahl, Anders, Kløw, Nils-Einar, Seljeflot, Ingebjørg, Andersen, Geir Øystein, Wiseth, Rune, Aukrust, Pål, Gullestad, Lars
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2019
Assuntos:
Protocol
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6803013/
https://ncbi.nlm.nih.gov/pubmed/31673391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/openhrt-2019-001108
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