Neu3 Sialidase-Mediated Ganglioside Conversion Is Necessary for Axon Regeneration and Is Blocked in CNS Axons

PNS axons have a high intrinsic regenerative ability, whereas most CNS axons show little regenerative response. We show that activation of Neu3 sialidase, also known as Neuraminidase-3, causing conversion of GD1a and GT1b to GM1 ganglioside, is an essential step in regeneration occurring in PNS (sen...

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Bibliografische gegevens
Gepubliceerd in:J Neurosci
Hoofdauteurs: Kappagantula, Sunil, Andrews, Melissa R., Cheah, Menghon, Abad-Rodriguez, José, Dotti, Carlos G., Fawcett, James W.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Society for Neuroscience 2014
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6802756/
https://ncbi.nlm.nih.gov/pubmed/24523539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4432-13.2014
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