Deacetylation of XBP1s by sirtuin 6 confers resistance to ER stress-induced hepatic steatosis

The active spliced form of X-box-binding protein 1 (XBP1s) is a key modulator of ER stress, but the functional role of its post-translational modification remains unclear. Here, we demonstrate that XBP1s is a deacetylation target of Sirt6 and that its deacetylation protects against ER stress-induced...

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Publicat a:Exp Mol Med
Autors principals: Bang, In Hyuk, Kwon, Oh Kwang, Hao, Lihua, Park, Dami, Chung, Myung-Ja, Oh, Byung-Chul, Lee, Sangkyu, Bae, Eun Ju, Park, Byung-Hyun
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6802632/
https://ncbi.nlm.nih.gov/pubmed/31541078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s12276-019-0309-0
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