Specific effects of antitumor active norspermidine on the structure and function of DNA

We compared the effects of trivalent polyamines, spermidine (SPD) and norspermidine (NSPD), a chemical homologue of SPD, on the structure of DNA and gene expression. The chemical structures of SPD and NSPD are different only with the number of methylene groups between amine groups, [N-3-N-4-N] and [...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Nishio, Takashi, Yoshikawa, Yuko, Shew, Chwen-Yang, Umezawa, Naoki, Higuchi, Tsunehiko, Yoshikawa, Kenichi
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6802174/
https://ncbi.nlm.nih.gov/pubmed/31628357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-50943-1
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