Stabilization of c-KIT G-Quadruplex DNA Structures by the RNA Polymerase I Inhibitors BMH-21 and BA-41

The stabilization of G-quadruplex DNA structures by small molecules with affinity to oncogene promoters has emerged as a promising anticancer strategy, due to a potential role in gene expression regulation. We explored the ability of BMH-21 (1) and its analogue BA-41 (2) to bind the G-quadruplex str...

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Veröffentlicht in:Int J Mol Sci
Hauptverfasser: Mazzini, Stefania, Gargallo, Raimundo, Musso, Loana, De Santis, Francesca, Aviñó, Anna, Scaglioni, Leonardo, Eritja, Ramon, Di Nicola, Massimo, Zunino, Franco, Amatulli, Annabella, Dallavalle, Sabrina
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6801708/
https://ncbi.nlm.nih.gov/pubmed/31590335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20194927
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