Nucleoside diphosphate-linked moiety X-type motif 15 R139C genotypes impact 6-thioguanine nucleotide cut-off levels to predict thiopurine-induced leukopenia in Crohn’s disease patients

BACKGROUND: Thiopurine-induced leukopenia (TIL) is a life-threatening toxicity and occurs with a high frequency in the Asian population. Although nucleoside diphosphate-linked moiety X-type motif 15 (NUDT15) variants significantly improve the predictive sensitivity of TIL, more than 50% of cases of...

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Detalhes bibliográficos
Publicado no:World J Gastroenterol
Main Authors: Zhu, Xia, Chao, Kang, Li, Miao, Xie, Wen, Zheng, Hong, Zhang, Jin-Xin, Hu, Pin-Jin, Huang, Min, Gao, Xiang, Wang, Xue-Ding
Formato: Artigo
Idioma:Inglês
Publicado em: Baishideng Publishing Group Inc 2019
Assuntos:
Retrospective Study
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6801191/
https://ncbi.nlm.nih.gov/pubmed/31636477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3748/wjg.v25.i38.5850
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