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Simultaneous quantification of ondansetron and tariquidar in rat and human plasma using HPLC-UV
Ondansetron, a widely used antiemetic agent, is a P-glycoprotein (P-gp) substrate and therefore expression of P-gp at the blood-brain barrier limits distribution of ondansetron to the central nervous system (CNS), which was observed to be reversed by co-administration with P-gp inhibitors. Tariquida...
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| Publicado no: | Biomed Chromatogr |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6800589/ https://ncbi.nlm.nih.gov/pubmed/31322284 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bmc.4653 |
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