BIRC5 Gene Disruption via CRISPR/Cas9n Platform Suppress Acute Myelocytic Leukemia Progression

BACKGROUND: Acute myelocytic leukemia (AML) is a clonal malignancy resulting from the accumulation of genetic abnormalities in the cells. Human baculoviral inhibitor of apoptosis repeat-containing 5 (BIRC5), encodes survivin, is one of only a handful of genes that is differentially over-expressed in...

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Bibliografiske detaljer
Udgivet i:Iran Biomed J
Main Authors: Narimani, Manizheh, Sharifi, Mohammadreza, Hakhamaneshi, Mohammad Saeed, Roshani, Daem, Kazemi, Mohammad, Hejazi, Seyed Hossein, Jalili, Ali
Format: Artigo
Sprog:Inglês
Udgivet: Pasteur Institute of Iran 2019
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6800533/
https://ncbi.nlm.nih.gov/pubmed/31104397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.29252/ibj.23.6.369
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