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Distinct substrate specificities of the human tRNA methyltransferases TRMT10A and TRMT10B

The tRNA m(1)R(9) methyltransferase (Trm10) family is conserved throughout Eukarya and Archaea. Despite the presence of a single Trm10 gene in Archaea and most single-celled eukaryotes, metazoans encode up to three homologs of Trm10. Several disease states correlate with a deficiency in the human ho...

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Detalhes bibliográficos
Publicado no:RNA
Main Authors: Howell, Nathan W., Jora, Manasses, Jepson, Benjamin F., Limbach, Patrick A., Jackman, Jane E.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6800469/
https://ncbi.nlm.nih.gov/pubmed/31292261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.072090.119
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