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N-terminal alternative splicing of GluN1 regulates the maturation of excitatory synapses and seizure susceptibility
The majority of NMDA receptors (NMDARs) in the brain are composed of 2 GluN1 and 2 GluN2 subunits. The inclusion or exclusion of 1 N-terminal and 2 C-terminal domains of GluN1 results in 8 splicing variants that exhibit distinct temporal and spatial patterns of expression and functional properties....
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| Publicado no: | Proc Natl Acad Sci U S A |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6800312/ https://ncbi.nlm.nih.gov/pubmed/31570583 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1905721116 |
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