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miR-124/VAMP3 is a novel therapeutic target for mitigation of surgical trauma-induced microglial activation

Activation of microglia and the subsequently elevated inflammatory cytokine release in the brain during surgery predispose individuals to cognitive dysfunction, also known as postoperative cognitive dysfunction (POCD). miR-124 is one of the most abundant microRNAs in the brain that regulates microgl...

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Bibliografiske detaljer
Udgivet i:Signal Transduct Target Ther
Main Authors: Chen, Yan, Sun, Jing-xian, Chen, Wan-kun, Wu, Gen-cheng, Wang, Yan-qing, Zhu, Ke-ying, Wang, Jun
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6799846/
https://ncbi.nlm.nih.gov/pubmed/31637007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41392-019-0061-x
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