3213 Unraveling the role of Phospholamban (PLN) in humans via the characterization of Induced Pluripotent Stem Cell (iPSC) Cardiomyocytes (CM) derived from carriers of a lethal PLN mutation

OBJECTIVES/SPECIFIC AIMS: To study the biology of Phosholamban (PLN) in a human relevant model. METHODS/STUDY POPULATION: State of the art stem-cell technologies using iPSC-CMs derived from carriers of a lethal PLN mutation. RESULTS/ANTICIPATED RESULTS: Our preliminary data demonstrate that this par...

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Detalhes bibliográficos
Publicado no:J Clin Transl Sci
Main Authors: Trivieri, Maria Giovanna, Stillitano, Francesca, Ceholski, Delaine, Turnbull, Irene, Costa, Kevin, Weber, Thomas, Fish, Kenneth, Kranias, Evangelia, Hajjar, Roger
Formato: Artigo
Idioma:Inglês
Publicado em: Cambridge University Press 2019
Assuntos:
Basic/Translational Science/Team Science
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6799595/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1017/cts.2019.62
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