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2064: Deconstructing the peptide specificity of TCR recognition

OBJECTIVES/SPECIFIC AIMS: The off-target and organ-specific toxicities observed in cancer immunotherapy present an obstacle to T-cell-based therapeutics. A recent clinical trial underscored the need for improved methods to define TCR specificity after melanoma patients treated with TCR engineered T-...

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Publicado en:J Clin Transl Sci
Main Authors: Riley, Timothy P., Mendoza, Juan, Garcia, K. C., Baker, Brian M.
Formato: Artigo
Idioma:Inglês
Publicado: Cambridge University Press 2018
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6799170/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1017/cts.2017.195
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