Polymyxin resistance in Klebsiella pneumoniae: multifaceted mechanisms utilized in the presence and absence of the plasmid-encoded phosphoethanolamine transferase gene mcr-1

OBJECTIVES: Until plasmid-mediated mcr-1 was discovered, it was believed that polymyxin resistance in Gram-negative bacteria was mainly mediated by the chromosomally-encoded EptA and ArnT, which modify lipid A with phosphoethanolamine (pEtN) and 4-amino-4-deoxy-l-arabinose (l-Ara4N), respectively. T...

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Bibliografski detalji
Izdano u:J Antimicrob Chemother
Glavni autori: Nang, Sue C, Han, Mei-Ling, Yu, Heidi H, Wang, Jiping, Torres, Von Vergel L, Dai, Chongshan, Velkov, Tony, Harper, Marina, Li, Jian
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2019
Teme:
Original Research
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6798846/
https://ncbi.nlm.nih.gov/pubmed/31365098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkz314
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