Development of a novel human phage display-derived anti-LAG3 scFv antibody targeting CD8(+) T lymphocyte exhaustion

BACKGROUND: Lymphocyte-activation gene (LAG)3 is a 498 aa transmembrane type I protein acting as an immune inhibitory receptor. It is expressed on activated lymphocytes, natural killer cells and plasmacytoid dendritic cells. In activated lymphocytes, LAG3 expression is involved in negative control o...

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Библиографические подробности
Опубликовано в: :BMC Biotechnol
Главные авторы: Ascione, Alessandro, Arenaccio, Claudia, Mallano, Alessandra, Flego, Michela, Gellini, Mara, Andreotti, Mauro, Fenwick, Craig, Pantaleo, Giuseppe, Vella, Stefano, Federico, Maurizio
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2019
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6798348/
https://ncbi.nlm.nih.gov/pubmed/31623599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12896-019-0559-x
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