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Janus Kinase 1 Is Required for Transcriptional Reprograming of Murine Astrocytes in Response to Endoplasmic Reticulum Stress

Neurodegenerative diseases are associated with the accumulation of misfolded proteins in the endoplasmic reticulum (ER), leading to ER stress. To adapt, cells initiate the unfolded protein response (UPR). However, severe or unresolved UPR activation leads to cell death and inflammation. The UPR is i...

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Détails bibliographiques
Publié dans:Front Cell Neurosci
Auteurs principaux: Sims, Savannah G., Meares, Gordon P.
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2019
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6797841/
https://ncbi.nlm.nih.gov/pubmed/31680865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2019.00446
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