Stimulation of Mononuclear Cells Through Toll-Like Receptor 9 Induces Release of Microvesicles Expressing Double-Stranded DNA and Galectin 3-Binding Protein in an Interferon-α-Dependent Manner

Background: Microvesicles (MVs) expressing the type 1 interferon (IFN)-inducible protein galectin-3 binding protein (G3BP) may play a pathogenic role in systemic lupus erythematosus (SLE). Co-expression of double-stranded DNA (dsDNA) on such MVs may render them immunogenic and targets for anti-dsDNA...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Rasmussen, Niclas Stefan, Nielsen, Christoffer Tandrup, Jacobsen, Søren, Nielsen, Claus Henrik
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6797593/
https://ncbi.nlm.nih.gov/pubmed/31681284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.02391
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