Obesity Mediates Apoptosis and Extracellular Matrix Metabolic Imbalances via MAPK Pathway Activation in Intervertebral Disk Degeneration

Obesity may promote intervertebral disc degeneration (IDD) by non-mechanical means, by influencing levels of free fatty acids which could impair cell metabolism. This study aims to establish metabolic factors in obesity-related IDD independent of mechanical loading. In clinical study, we retrospecti...

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Pubblicato in:Front Physiol
Autori principali: Zhang, Xuyang, Chen, Jian, Huang, Bao, Wang, Jiasheng, Shan, Zhi, Liu, Junhui, Chen, Yilei, Li, Shengyun, Fan, Shunwu, Zhao, Fengdong
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2019
Soggetti:
Physiology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6796795/
https://ncbi.nlm.nih.gov/pubmed/31649558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2019.01284
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