Dual lysosomal-mitochondrial targeting by antihistamines to eradicate leukaemic cells

BACKGROUND: Despite great efforts to identify druggable molecular targets for AML, there remains an unmet need for more effective therapies. METHODS: An in silico screening was performed using Connectivity Maps to identify FDA-approved drugs that may revert an early leukaemic transformation gene sig...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:EBioMedicine
Main Authors: Cornet-Masana, Josep M., Banús-Mulet, Antònia, Carbó, José M., Torrente, Miguel Ángel, Guijarro, Francesca, Cuesta-Casanovas, Laia, Esteve, Jordi, Risueño, Ruth M.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2019
Fag:
Research paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6796581/
https://ncbi.nlm.nih.gov/pubmed/31473184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2019.08.021
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker