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P11.07 LAPTM5 functions as a tumor suppressor via CD40 - NFêB pathway inhibition and represents a potential biomarker for temozolomide sensitivity in CD40 proficient glioblastoma

BACKGROUND: Glioma therapy is challenged by the invasive nature of glioma resulting in tumor recurrence and treatment resistance. Lysosomal protein transmembrane 5 (LAPTM5) was identified to inhibit invasion by screening for invasion-associated genes in glioma. The aim of this study was to decipher...

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Publicat a:Neuro Oncol
Autors principals: Berberich, A, Bartels, F, Tang, Z, Pusch, S, Hucke, N, Kessler, T, Dong, Z, Wiestler, B, Winkler, F, Platten, M, Wick, W, Abdollahi, A, Lemke, D
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6796169/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz126.153
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